Safety and Effectiveness of Topical Epinephrine in Pediatric Dentistry | State News

LAWRENCE, Kan., October 9, 2021 / PRNewswire-PRWeb / – Advances in Anesthesia – The most common chronic disease in children is tooth decay, and routine pediatric dental care is a necessity that contributes to oral and overall health from the body. However, the majority of children will still need some form of restorative dental care, and this increases in those who do not receive routine dental check-ups. Safety and effectiveness of treatment are imperative when performing pediatric dental procedures.

Researchers from the University of Washington, Seattle; Evidinno Outcomes Research Inc., Vancouver, British Columbia, Canada; and the University of Missouri-Kansas City School of Dentistry, Kansas City, Missouri, recently published a single-blind, crossover / split-mouth randomized controlled trial in the current issue of Anesthesia Progress that compared the cardiovascular safety and hemostatic efficacy of topical epinephrine with a saline placebo.

A total of 13 patients (54% male / 46% female), aged 2.7 to 7.8 years and requiring zirconia crowns on the maxillary first primary molars, participated in this study. The researchers measured heart rate (HR), diastolic and systolic blood pressure (D / SBP), and mean arterial pressure (MAP) while the patient was under general anesthesia to monitor cardiovascular function, as well as to track time. necessary to achieve hemostasis as a measure of clinical efficacy. Patients’ heart rate, D / SBP, and MAP were recorded immediately prior to epinephrine or saline pellet placement (baseline), then 1, 2, 3, 4, and 5 minutes after removal nerve.

Researchers found significant decreases in heart rate, D / SBP, and PAD from baseline 5 minutes after epinephrine treatment. In the placebo group, there were significant decreases in HR and SBP, but no significant change in DBP or MAP. During the recording times, there were no clinically significant changes in cardiovascular measures and no adverse events in either group. The researchers also note that all 13 teeth in the epinephrine group achieved adequate hemostasis within 2.2 minutes, while only 5 of 13 placebo teeth achieved hemostasis within the 5-minute observation window; the remaining 8 teeth required an injection of local anesthetic and the application of direct pressure to achieve hemostasis.

The results of this study suggest that the use of epinephrine lozenges when placing a zirconia crown under general anesthesia in children does not have negative cardiovascular effects and that hemostasis is achieved more quickly. and more efficiently. On the results of this study, the main author Afsoon Fazeli says: “We were reassured by the results of the study, but we hope that there will be more clinical studies so that dentists can feel confident in using epinephrine lozenges to improve their effectiveness. during procedures without worrying about cardiovascular side effects ”.

Full text of the article, “Cardiovascular Safety and Hemostatic Efficacy of

Epinephrine in Children Receiving Zirconia Crowns, “Anesthesia Progress, Vol. 68, No. 3, 2021, is available at: https://meridian.allenpress.com/anesthesia-progress/article/68/3/133/471172/Cardiovascular-Safety-and-Hemostatic-Efficacy-of

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About advances in anesthesia

Anesthesia Progress is the official publication of the American Dental Society of Anesthesiology (ADSA). The quarterly journal is dedicated to providing a better understanding of advancements in the science of pain and anxiety control in dentistry. The journal invites submissions of review articles, clinical technique reports, case reports and conference abstracts. To learn more about ADSA, visit: http://www.adsahome.org/.

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Samantha weinkauf, Allen press, +1 (785) 865-9123, sweinkauf@allenpress.com

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